Studies: Puberty blockers results in happy young adults; “Hormone imbalance” not a factor in trans identity

avery jackson mtvLEXIE CANNES STATE OF TRANS — Research findings from a Dutch study on trans youth indicates puberty blockers (aka hormone therapy) indicates a significant increased “opportunity to develop into well-functioning young adults.” The study finds the quality of life for them post-treatment were the same as their cis counterparts, with no participants in the study expressing regret and overall satisfied with their decisions. Likewise the happiness factor matched cis peers.

The study’s lead researcher, Dr. Annelou de Vries in the medical journal Pediatrics:

 “Since puberty suppression is a fully reversible medical intervention, it provides adolescents and their families with time to explore their gender dysphoric feelings, and [to] make a more definite decision regarding the first steps of actual gender reassignment treatment at a later age. By delaying the onset of puberty, those children who go on to gender reassignment “have the lifelong advantage of a body that matches their gender identities without the irreversible body changes of a low voice or beard growth or breasts, for example.”

De Vries is with Amsterdam’s VU University Medical Center’s Center of Expertise on Gender Dysphoria.

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Researchers at Los Angeles’ Children’s Hospital Center for Transyouth Health have closed the door on the link between trans identity and hormone imbalance — there isn’t one. The center’s Medical Director, Dr. Johanna Olson as published in The Advocate: “We’ve now put to rest the residual belief that transgender experience is a result of a hormone imbalance.”

Other findings in the study of which there were over 100 participants — a bit more than 50% of the people in the study considered suicide with 30% making an attempt. This is not far off base from earlier research studies on trans suicide (see link below “suicide stats”).

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Trans suicide stats: https://lexiecannes.com/stats-on-transgender-discrimination-violence-and-suicide/

Puberty blockers: http://www.cbsnews.com/news/transgender-teens-become-happy-healthy-young-adults/

Hormone imbalance: http://www.advocate.com/transgender/2015/07/22/study-transgender-youth-do-not-have-hormonal-imbalance

avery jackson mtv

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Read Lexie Cannes in The Huffington Post: http://www.huffingtonpost.com/courtney-odonnell/



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26 replies

  1. I do volunteer work with a youth support group and see this first hand. To watch a child go from depressed and sad to being happy with who they are is one of the most rewarding events I have ever witnessed.

    • I have great hope for a grandniece who spent her 4th birthday as a fairy princess and was recently asked in kindergarten why she was so unhappy. Her reply, “Because I have to wear these ‘man’ clothes.”
      Now she’s better after a trip to the store and the others at school are “finally starting to get it”.
      Some day she will automatically reach for something, and her hands will be there to do it, and when she takes a step, there will be ground beneath her feet.

  2. Finally, the medical world is coming to it’s senses.

  3. Oh the transgender children today are so lucky. I envy them, but by the same token I wish them all the happiness in the world. As an older transgender woman, I have tried to show, in speaking engagements, how it was in the “bad old days” when if you were transgender you could be sent to an inane asylum for reparative treatment. Or at best, like I was, sent to a criminal psychologist for treatment (mine was connected to the Trenton State Penitentiary in New Jersey). I am not saying that there aren’t still transgender children who have to endure the narrow mindedness of the uneducated people, whether those people are relatives or strangers. What I am saying is that these children have so many more accepting and mentoring places to go to now than even 10 years ago, and we as a nation must continue to support these young people with these services.

  4. This is not a new study, the article on puberty blockers that is linked is from last year. The fact is that this doctor from Denmark is making a misstatement in stating that puberty blockers are reversible, that is simply not true. The most recent opinion by Abbott Laboratories, the maker of Lupron, does not reflect that. How can you post something that doctors can’t even conclusively validate? Dr. Courtney Finlayson, M.D. at Lurie Children’s Hospital has said that they hope that what they are doing in treating children to transition with puberty blockers is the right thing to do. She said that she knows that these kids will be teaching them.

    • While people are entitled to their own opinions, Ms. Lopez’s opinions are contrary to those held by most trans professionals. For further background on Ms. Lopez, you can read her own words here: https://lexiecannes.com/2015/06/24/trans-man-says-the-earth-is-flat-nonsense-easily-debunked-101/

      • Do I dare address the false claim about Lupron and Central Precocious Puberty when the only mention of something not being “reversible” on their webpage concerns adult endometriosis? It’s long…..

        • No, again our views are completely misstated. Abbott Laboratories has stated that the use of Lupron in children has not been validated to be reversible, yet the medical community makes the point to contradict the manufacturer and says that it’s use is indeed reversible.

        • There again you are incorrect in your assumptions.

          • Here is a link to an article which just points out the fact of what we are saying: these children are lab rats for the medical community to experience with.

            http://www.npr.org/sections/health-shots/2015/07/22/424996915/health-effects-of-transitioning-in-teen-years-remain-unknown

            Dr. Finlayson was cited from the PBS Frontline “Growing Up Trans” documentary that aired last month and is available to view on http://www.pbs.org. She states that they (the medical community) just does not know for sure if they are doing the right thing by transitioning children, she hopes that they are. The Lurie Children’s Clinic received a sizable donation from billionaire Jennifer Pritzker, a well known crossdresser who transitioned in late 2013. Dr. Rob Garofalo was put in charge of a program that he knew very little about.

            With regards to Abbott Laboratories they state, “studies have not been completed in children to determine the full reversibility of fertility suppression.” This statement stands in dealing with all manner of puberty suppression regardless of CPB or in transitioning young children.

            The fact is that if one child is misdiagnosed by these trans professionals and they are stunted and unable to be fertile in the future it will have been one child too many. The risks are far too great for this current generation to be sacrificed to this obsessed medical community. They do not care about the welfare of children, the medical community sold out to their oath decades ago, why do you continue to trust modern day drug pushers. That’s right these people find the “solution” to what ails us is to be found in the god of drugs. This is not how we were designed to exist on this planet. Why can’t we all realize that we are all in danger here???

      • Lexie, with all due respect, I had submitted a rebuttal to your claims, but you never allowed it to be posted here. For the record it is Mrs. Cummings that I am officially known as these days. Mark and I married in a lovely ceremony on July 16 and had a wonderful celebration of our vows just last Saturday. If you would allow our counterpoints to be seen, your readers would see that we are indeed intelligently presenting a valid opinion here.

        • Lynna, Your first post was your rebuttal opportunity. And you posted 4 more times in this thread since then. One really only needs to post one rebuttal and move on. If your argument is persuasive, people will buy it the first time you post. Repeating it over and over again is not going to change things.

          You may call yourself Mrs. Cummings, but your username says Lynna Lopez.

      • [Moderator comment: Mark Angelo has used up his get-out-of-jail card last June, hence is no longer able to get past this blog’s auto-gatekeeper. I am letting this post go through as a confirmation of the correct decision to suspend his posting privileges.]

        “Trans professionals”, that’s like calling the head of anorexia a diet guru. These clowns are making things up as they go along, and all of you are loving it, cause it justifies your illusions. It amazes that the only condition that is being allowed to be self diagnosed and treated is gender dysphoria, the group has prompted their own “medical professionals” to create their treatment and anyone who goes against their protocol are dismissed. You people are a joke. A bunch of men wearing, calling themselves women and buying their way into the golden club. Of coarse my comment will be deleted and called ad hominem. A true female always gets silenced.

        • I appreciate you being willing to post my husband’s statements, but your lack of allowing him to fully express here really hurts your credibility in giving a voice to all and for allowing true debate to exist. It’ unfortunate that dissenting opinion has to be silenced.

    • I’m sorry, but I couldn’t find that quote from Courtney Finlayson. Was it at the Northwestern Oncofertility Conference or in the “Windy City Times” article “Inside Lurie Children’s gender/sex program”:
      http://www.windycitymediagroup.com/lgbt/Inside-Lurie-Childrens-gender-sex-program-Part-1-of-3/47235.html

      Wherever it was found, I’m sure she’ll find the same sequences as others:
      “Puberty Suppression in a Gender-Dysphoric Adolescent: A 22-Year Follow-Up” 2011
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114100/
      “He was functioning well psychologically, intellectually, and socially; however, he experienced some feelings of sadness about choices he had made in a long-lasting intimate relationship. There were no clinical signs of a negative impact on brain development. He was physically in good health, and metabolic and endocrine parameters were within reference ranges. Bone mineral density was within the normal range for both sexes. His final height was short as compared to Dutch males; however, his body proportions were within normal range. This first report on long-term effects of puberty suppression suggests that negative side effects are limited and that it can be a useful additional tool in the diagnosis and treatment of gender dysphoric adolescents.”
      “At the Dutch gender identity clinic, none of the adolescents diagnosed with GID and treated with GnRH analogs refrained from further treatment procedures or regretted gender reassignment.”

      This last, according to Spack, included surgical reassignment and not merely social:
      “Charlie Rose, The Brain Series: Gender Identity”
      http://charlierose.com/watch/60578677

      However, regarding your unattributed comment about Abbot and Lupron, the only reference I found of not being “reversible” was its use for adult endometriosis, NOT Central Precocious Puberty (CPP). This referred to bone thinning; thus the recommended addition of norethindrone acetate to prevent such states in susceptible adults. Indeed, the opposite is found in use as an early blocker:
      “At the start of GnRHa treatment, all patients had normal bone mineral density, Delemarre-van de Waal reported. During GnRHa treatment, bone density gradually increased in the younger patients but slightly decreased in the older ones. However, after the teens received cross-sex hormones, bone density caught up, similar to the increase that occurs naturally in puberty, she said. All patients had normal or near-normal bone mass for their age after cross-sex hormone therapy.”

      “Remarkably, the highest bone mineral density was in the patients who had started hormonal intervention with GnRHa at an early pubertal stage,” she said. “These findings reaffirm that halting puberty in gender-dysphoric adolescents is a responsible practice that will not harm bone health.””
      “Medical intervention in transgender adolescents appears to be safe and effective” 2013
      http://www.sciencecodex.com/medical_intervention_in_transgender_adolescents_appears_to_be_safe_and_effective-114120

      The only other major question in “reversible” was answered long ago, as this study shows:
      “Human male patients lacking GnRH and treated with hormone therapy can remain fertile after cessation of treatment suggesting that new GnRH neurons can be generated during adult life. We used zebrafish to investigate the neurogenic potential of the adult hypothalamus.”
      “Finally, we show in vivo that a neurogenic niche in the hypothalamus contains GnRH positive neurons. Thus, we demonstrated for the first time that neurospheres can be derived from the hypothalamus of the adult zebrafish and that these neural progenitors are capable of producing GnRH containing neurons.”
      “Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons.”
      http://www.ncbi.nlm.nih.gov/pubmed/26209533

      And the proximal neurology between zebrafish and humans is close enough to determine other factors, such as the dopamine-dopal-apoptosis relationship in Parkinsonian states:
      “Dopamine toxicity and oxidative stress in zebrasifh larvae as a model of Parkinon’s disease neuropathology”
      http://www.studiopollex.com/sfn/stednitz_poster.pdf

      But I suspect you’re merely doing what John Grant in “Denying Science” called magnifying disputes among scientists, or should I ask WHY you would post such a misleading and obviously intended claim about Lupron? And to couch it in such a manner as to be concerned with the well being of others? If you were so, perhaps you would be better served by preventing the need for Abbots erudite and forward-looking drug by informing others:
      “Association of aromatase (TTTA)n repeat polymorphisms with central precocious puberty in girls.”
      http://www.ncbi.nlm.nih.gov/pubmed/?term=estrogen+aromatase
      “The cytochrome P450 19A1 (CYP19A1) gene encodes an aromatase that is responsible for the conversion of androgens to oestrogen, which is a key step in oestrogen biosynthesis.”

      “CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls.”
      http://www.ncbi.nlm.nih.gov/pubmed/24649863

      “Histone Methyltransferase EZH2 Is Transcriptionally Induced by Estradiol as Well as Estrogenic Endocrine Disruptors Bisphenol-A and Diethylstilbestrol.”
      http://www.ncbi.nlm.nih.gov/pubmed/25088689
      “In summary, we demonstrate that EZH2 is transcriptionally regulated by estradiol in vitro and in vivo, and its expression is potentially dysregulated upon exposure to estrogenic EDCs.”

      “Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice.”
      http://www.ncbi.nlm.nih.gov/pubmed/24603706

      “Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis.”
      http://www.ncbi.nlm.nih.gov/pubmed/24654751

      “High urinary phthalate concentration associated with delayed pubarche in girls.”
      http://www.ncbi.nlm.nih.gov/pubmed/22428786
      “We demonstrated that delayed pubarche, but not thelarche, was associated with high phthalate excretion in urine samples from 725 healthy school girls, which may suggest anti-androgenic actions of phthalates in our study group of girls.”
      –Small breasts and no hair, a pedophile’s dream. Breast buds at six and menarche at 8 is a thing of the present, along with cancers.

      “Di-n-butyl phthalate causes estrogenic effects in adult male Murray rainbowfish (Melanotaenia fluviatilis).”
      http://www.ncbi.nlm.nih.gov/pubmed/24576492

      “A critical assessment of the endocrine susceptibility of the human testis to phthalates from fetal life to adulthood”
      http://humupd.oxfordjournals.org/content/20/2/231
      “epidemiological and in vitro studies generally converge sufficiently to conclude that phthalate anti-androgenicity is plausible in adult men.”

      “Prenatal phthalate exposure and reduced masculine play in boys” Swan et al, International Journal of Andrology, Volume 33, Issue 2, pages 259–269, April 2010″
      http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2605.2009.01019.x/abstract

      “Effects of maternal exposure to a low dose of diethylstilbestrol on sexual dimorphic nucleus volume and male reproductive system in rat offspring.” Yamamoto et al, 2005
      https://www.ncbi.nlm.nih.gov/pubmed/15800398
      “Of the 10 pregnant rats in the DES 4.5 group, only 1 delivered, and this rat could not suckle the pups…The testosterone concentrations in the DES 1.5 and 0.5 groups at 6 weeks were significantly decreased and the plasma LH concentrations were not altered.”
      “In the DES 1.5 group, DES treatment did not change the volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) in the male offspring, although this dose of DES increased the volume of SDN-POA in female offspring.”
      “These observations indicate that prenatally administered DES impairs testicular endocrine function continuously as well as pituitary function, but the induced low level of testosterone disrupts spermatogenesis and permanently inhibits the morphological development of epididymis and prostate.”

      “Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7”
      http://journalistsresource.org/studies/society/health/prenatal-pah-exposure-child-behavior-problems/#
      “The results suggest an adverse impact of prenatal PAH exposure on child behavior that could impact cognitive development and ability to learn,” the researchers conclude. “Anxiety, depression and attention problems, which were associated with PAH exposure … have been shown to affect subsequent academic performance.”

      “Endocrine disruption of the epigenome: a breast cancer link.”
      http://www.ncbi.nlm.nih.gov/pubmed/24532474
      “”The heritable component of breast cancer accounts for only a small proportion of total incidences. Environmental and lifestyle factors are therefore considered to among the major influencing components increasing breast cancer risk. Endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment. The estrogenic property of EDCs has thus shown many associations between ongoing exposures and the development of endocrine-related diseases, including breast cancer.”

      Full Text:
      http://erc.endocrinology-journals.org/content/21/2/T33.long
      “”Importantly in mammals, exposure of gestating females to environmental factors or toxicants during the period of gonadal sex determination can alter epigenetic transgenerational inheritance.”

      “Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure.”
      http://www.ncbi.nlm.nih.gov/pubmed/16690810

      “The development of gender-related behavior in females following prenatal exposure to diethylstilbestrol (DES)”
      http://www.sciencedirect.com/science/article/pii/0018506X89900408
      “Animal research has shown that diethylstilbestrol (DES) present during the sensitive developmental periods of the hypothalamus and adjacent areas of the brain affects the development of sex-dimorphic brain structures and subsequent behavior.”
      “The mothers of these women were interviewed about their daughters with the “mother form” of the same interview schedule. The results suggest that DES women show less orientation toward parenting than the controls.”

      “Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients.”
      http://www.sciencedirect.com/science/article/pii/S0306453012003307

      “Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure.”
      http://www.pnas.org/content/110/24/9956.short
      “Importantly, changes in ERa and DNMT expression in the cortex (males) and hypothalamus (females) were associated with DNA methylation changes in the ERa gene. BPA exposure induced persistent, largely sex-specific effects on social and anxiety-like behavior, leading to disruption of sexually dimorphic behaviors. Although postnatal maternal care was altered in mothers treated with BPA during pregnancy, the effects of in utero BPA were not found to be mediated by maternal care.”

      Considering that function follows form just as neurology defines behavior, can it be said that, as the possible germinant of the current social enthrallment with Zombies, all brainwashed in the same laundry, that persons whose cortices and hypothalami have been chemically affected to exhibit greater disgust, female relational aggression, fear, anxiety and paranoia via a variant BSTc and its amygdalar effect, and decreased parenting interest; can they, compared to pre-industrial females, be called “real” women? The point is moot of course, but the cancers, autoimmune diseases, developmental delays, disorders of sexual development, ADHD, and lowered IQ are not.
      I leave you with slim hope:
      According to “An Update on Plant Derived Anti-Androgens”-
      http://endometabol.com/?page=article&article_id=3644
      -black cohosh inhibits the proliferation of breast cancer cells and causes cancer cell death (apoptosis) in prostate cancer whether they’re androgen-dependent or not.
      According to “Endocrine disruption of the epigenome: a breast cancer link” (long), complete soy isoflavones and tomato’s lycopene may inhibit some breast cancers, but time of use or application, in utero/early childhood, may be important (miso soup just like Mama used to make). Complications: Soy isoflavones have been shown to decrease incidence but increase grade of cancer when it’s there–and soy is an aromatase promoter. Aromatase changes testosterone into estrogen and is contraindicated in estrogen-dependent cancers.
      Red clover contains isoflavones.
      All are proscribed during pregnancy according to WebMD, and when cancer is present or passed.

      • An attribution: for Abbot’s “Important Safety Information”, see:
        http://www.lupron.com/
        “WOMEN Endometriosis” and “CHILDREN Central Precocious Puberty (CPP)”

        • The fact is that treating children, who are said to be dealing with gender dysphoria, with leuprolide acetate, a chemotherapy drug with a very tainted and questionable past, is beyond irresponsible and a reckless practice to engage in. Any particular treatment usually goes through a battery of tests for decades at a time before the said drug is considered a safe treatment for the general public. Why do children have to be used as the test subjects as Dr.Finlayson, in another segment of the “Growing Up Trans” documentary clearly states is what is truly happening here. I encourage you to watch this well done documentary on trans children and which inadvertently showcases the doctors who treat them without being able to give them and their concerned parents any real answers to what lies ahead in the future. We are simply concerned that these touted trans professionals don’t really know anything at all, they are stabbing in the dark and have nothing to go by. Welcome to the wild west of modern medicine: transitioning children.

      • I hope that you see that everything that I am stating can be backed up with references and I have done so. We are not here to just be controversial, both Mark and I have legitimate concerns that we feel have a place in the debate over transitioning children. We can also just move right over puberty blockers anyway, because doctors like Spack and Olson are looking to circumvent puberty suppression drugs and are advocating for the use of cross-sex hormones on younger and younger youth, which we already know just how dangerous they are. So much so that post-menopausal women are encouraged not to use hormone replacement therapy because of the known dangers of synthetic hormones. Now these doctors are seeking to use these same hormones on children who have not even begun puberty. We know why that is so, perhaps because treating gender variant children is more cost effective and financially feasible for a larger group of kids out there. We all know that just the expense of puberty suppression drug treatment ($17000.00 per year for hystrelin implant for example) is far out of reach for many, but hormones are relatively cheap and affordable.

        • All you’ve done is use the 2007 study mentioned by NPR to deny recent studies that solve the problems of the earlier study. Without offering basis, reason, or argument.
          Hyperbole, fear mongering, defamatory comments about researchers/doctors/clinics/specialists, and quoting a poorly researched and presented article do NOT represent “legitimate concerns”; neither do they demonstrate non-reversibility.

          For instance, in what regard was Dr Stephen Rosenthal’s comment, “We have no way of assessing what would be the best way of caring for these people,” made? Because the NPR article certainly doesn’t state it.
          Was he referring to the lack of knowledge by the medical community regarding transgender persons? The denial of services by insurance companies? Had the NPR writer, Angus Chen, researched Dr Rosenthal, he might have read “Approach to the patient: transgender youth: endocrine considerations.” Rosenthal SM, Dec. 2014 –
          Full text:
          http://press.endocrine.org/doi/10.1210/jc.2014-1919?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
          – wherein he states “Although endocrinologists are familiar with concerns surrounding gender identity in patients with disorders of sex development, many providers are unfamiliar with the approach to the evaluation and management of transgender youth without a disorder of sex development. The goals of this article are to review studies that shed light on the biological underpinnings of gender identity, the epidemiology and natural history of transgenderism, current clinical practice guidelines for transgender youth, and limitations and challenges to optimal care.”
          – “Optimal care”

          This is in keeping with others who see a paucity of services:
          “[Psycho-medical care of transsexuals in Spain in the era of depathologization of transsexualism as a mental disorder. An overall review].”
          http://www.ncbi.nlm.nih.gov/pubmed/23916699
          “CONCLUSIONS:
          The access to hormonal and surgical treatment requires a profound review, and decentralization of transsexual care is recommended, because all university hospitals haves psychiatrists, clinical psychologists, and endocrinologists available. Although gender reassignment surgery also requires plastic surgery specialists, plastic surgeons currently receive training in this field.”

          AND:
          “Endocrine treatment of transsexual persons: extensive personal experience.” 2013
          Leinung MC, Urizar MF, Patel N, Sood SC.
          http://www.ncbi.nlm.nih.gov/pubmed/23512380
          “Transsexual persons seeking hormonal therapy are being seen with increasing frequency. The dysphoria present in many transsexual persons is associated with significant mood disorders that interfere with successful careers. Starting therapy at an earlier age may lessen the negative impact on mental health and lead to improved social outcomes. However, significant barriers exist, such as insufficient insurance coverage, which limit comprehensive care.”

          The NPR article doesn’t even say who “We” includes, but Rosenthal’s article states in case 1: “GnRH agonist treatment was prescribed; however, despite multiple appeals, this medication was denied by the family’s insurance company.”
          In case 2:
          “The patient’s gender dysphoria and suicidal ideation fully resolved, and the depression was markedly reduced.”
          – NONE of that sounds like they don’t know what they’re doing medically, as both you and NPR make it sound.

          They state that obesity and insulin resistance are “common” in transgender people; fyi, they’re also associated with phthalates:
          https://en.wikipedia.org/wiki/Phthalate#Other_effects
          – Just as the first stated negative side effects of gonadotropin stimulators (GnRH agonists) are all symptoms of menopause. This happens because stimulators cause “downregulation” of the receptors, and that’s why such drugs work–they cause the receptors to Not respond. This doesn’t mean it harms the gonadotropin system or pituitary, or the receptors, or fertility, and it’s why Abbot warns that worsening of symptoms can occur at the beginning of treatment before the receptors stop responding. Were mammals susceptible to naturally occurring GnRH agonists, they would have ceased to exist. Pulsatile secretion of gonadotropin/hormones and the resiliency and stability of the systems can be demonstrated, for instance, by increased cortisol production at day 130-135 prenatal to produce preparatory lung surfactant; were the endocrine system incapable of handling such actions, no one would “grow”.
          I’ve already demonstrated hypothalamic ability to produce new gonadotropic neurons.

          Leuprolide acetate is NOT a “chemotherapy drug”. It is an ancillary in prostate cancer, approved in 1985 (decades), and as a palliative for it, and is used in endometriosis and excessive fibroids. It does not kill cancer cells, doesn’t have the same side effects of chemotherapy drugs ad hoc, and naming it one is equal to saying aspirin heals broken bones–just as saying “only” 20% of patients eventually undergo transition is equal to saying Spanish Flu doesn’t exist because only one fifth of patients had it and died of it.

          As to Abbot’s statement that leuprolide acetate hasn’t been tested on child fertility, those conditions that would affect fertility, such as pituitary/hypothalamic adenoma or Leydig cell hypoplasia, would already be causing infertility problems and so cannot be used to study GnRH agonists, and neither would they be capable of responding to them. Overall, Abbot’s lackadaisical nature is a “good” thing, because it shows that the B- and GSAs are still adamant about Not submitting children for experiments by the insane.

          Many drugs are used for particular cancers, such as DES, still used in prostate cancers. Diethylstilbestrol is NOT a “chemotherapy drug”, it’s a synthetic estrogen, and…WE ALL KNOW WHAT HAPPENED THERE!
          “The Presence of Gender Dysphoria, Transsexualism, and Disorders of Sexual Differentiation in Males Prenatally Exposed to Diethylstilbestrol: Initial Evidence from a 5-Year Study” Scott Kerlin, Ph.D, 2004
          “More than 150 network members (out of 500) with “confirmed” or “strongly suspected” prenatal DES exposure identified as either “transsexual, pre- or post-operative,” (90 members), “transgender” (48 members), “gender dysphoric” (17 members), or “intersex” (3 members).”
          http://www.antijen.org/transadvocate/id33.html

          The FDA has banned non-prescription GnRH agonists, yet in your guise of “concern”, you would subject people to what the FDA and endocrinologists would prevent, a lifetime of menopause:
          “Sex differences in the neurokinin B system in the human infundibular nucleus.” 2012
          http://www.ncbi.nlm.nih.gov/pubmed/23019350
          “Quantitative analysis demonstrated that the human NKB system exhibits a robust female-dominant sexual dimorphism in the INF. During the first years after birth, both sexes displayed a moderate and equivalent level of NKB immunoreactivity in the INF. The adult features emerged progressively around puberty until adulthood, where the female-dominant sex difference appeared and continued into old age. *In MtF transsexuals, a female-typical NKB immunoreactivity was observed.* Finally, in postmenopausal women, there was a significant increase in NKB immunoreactivity compared to premenopausal women.”
          – Persons with a female INF and no estrogen experience gonadotropin overexpression and depletion with symptoms of menopause.

          See also: “The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons.”
          http://www.ncbi.nlm.nih.gov/pubmed/20529119

          As to “Growing Up Trans”, the studies that do exist show that most don’t continue? Why do they ignore present studies showing “By young adulthood, anxiety, emotional distress and body image concerns were no more prevalent among the transgender group than among the general public, the researchers determined. Also, quality of life and happiness levels were on par with their peers, gender dysphoria was no longer an issue, and no patients expressed regret about the transition process, including puberty delay.” (Alan Mozes, CBS News)
          – in lieu of dramatizing what’s been known for years, that not every case is trans or severe?

          “are advocating for the use of cross-sex hormones on younger and younger youth, which we already know just how dangerous they are.”
          – Do you mean what’s already known as Susan Maasch said at CBS: “But children usually go into puberty much earlier than that”?
          As has been confirmed by the “touted”?
          “[Adolescents with gender identity disorder: reconsideration of the age limits for endocrine treatment and surgery].” 2012, Nakatsuka M.
          http://www.ncbi.nlm.nih.gov/pubmed/22844815
          – Previously, I made it clear that pubertal onset, either in part or in full, was descending in age due to environmental causes.

          And as to your deprecation of HRT and that “which we already know”, Asscheman and others destroyed that fallacy:
          “The increased mortality in hormone-treated MtF transsexuals was mainly due to non-hormone-related causes, but ethinyl estradiol may increase the risk of cardiovascular death. In the FtM transsexuals, use of testosterone in doses used for hypogonadal men seemed safe.”
          “Our findings in 1989 (5) of an increased incidence of venous thrombosis associated with the use of ethinyl estradiol had already led to a change in type of estrogen prescription for new patients starting cross-sex hormones, and nowadays only few MtF use ethinyl estradiol or other oral estrogens in high dose. The increased risk of cardiovascular mortality was observed only in those who were still using ethinyl estradiol. No increased risk was found in former users who had changed to other formulations and lower doses of estradiol.”
          “A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones.”
          Full text, EJE, European Society of Endocrinology:
          http://eje-online.org/content/164/4/635.long

          AND:
          “Incidence of thrombophilia and venous thrombosis in transsexuals under cross-sex hormone therapy.” Ott et al, 2010
          http://www.ncbi.nlm.nih.gov/pubmed/19200981
          “VTE during cross-sex hormone therapy is rare. General screening for thrombophilic defects in transsexual patients is not recommended. Cross-sex hormone therapy is feasible in MtF as well as in FtM patients with aPC resistance.”

          These findings have been recognized by other touted peers:
          “Long-term cross-sex hormone treatment is safe in transsexual subjects” Meriggiola, Berra, 2012
          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720111/
          “The Asscherman paper therefore represents a very important and reassuring reference for professionals working in this field suggesting that mortality is increased among transsexuals although due to causes unrelated to cross sex replacement therapy. These results will benefit the care and treatment of these subjects.”

          As to your libel of Dr Garofalo, his opening statement, “The age limits, which used to say 18, now are 16, now you’re seeing people start cross-sex hormones at 15 or 14, and with the changes in the age of onset, come some challenges to care that I think teams need to be very savvy about” – is completely relevant to the present as has it been in the past:
          I’ve already shown how puberty is advancing due to EDCs (excluding nutritional factors), and Not always all the aspects of it (delayed pubarche but not thelarche). These are further complications of what professionals already do: “the general recommendation is watchful waiting and carefully observing how gender dysphoria develops in the first stages of puberty.” de Vries, Cohen-Kettenis et al, “Clinical management of gender dysphoria in children and adolescents: the Dutch approach.” 2012
          http://www.ncbi.nlm.nih.gov/pubmed/22455322

          Questions in the present and their lack of answers are elucidated by A. E. Brain here:
          http://aebrain.blogspot.com/2011/06/sexual-differentiation-of-human.html
          “Sexual differentiation of human behavior: effects of prenatal and pubertal organizational hormones.” 2011, Berenbaum SA, Beltz AM

          Questions in the future may be that those children who display counter-sex identification consistently because of an INAH3 that remains the same until the age of 10 (possibly descending) might/might not have a BSTc and Infundibular Nucleus that mature into puberty along the same chronology, thus factoring “certainty” defined by such structures and possibly expanding/contracting wait times;
          Will environmental factors affect brain growth causing exacerbation or delay of stress symptoms due to precocious maturation of body perception neura;
          Will measurable physiology and the parameters thereof maintain consistency and thus be used as definable markers for medical intervention;
          And for you personally, will someone weaponize a virus targeting the 12% of Mongolians with Genghis Kahn’s DNA and destroy their DMRT1 and thus turn all their bodies female, as in “Why can’t we all realize that we are all in danger here???”
          Did I mention the increased anxiety and paranoiac effects of BPA on the hypothalamus?

          Please be concise in your closing confabulations, alarmist misdirections, mistakes, and disinformation. I won’t reply further.

          • [Comment deleted by moderator. You cannot post comments on behalf of someone that is no longer allowed to post in here. That person has their own venue(s) and readers can view that person’s thoughts there.]

  5. I read an article last week stating that it was better, in that author’s opinion, to allow trans children to go thru puberty to harvest eggs and sperm for later making biological parenting possible for them. I am wondering how you and others feel about this?

    Thanks for your response

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